TY - JOUR
T1 - The feasibility of endocardial propagation mapping using magnetic resonance guidance in a swine model, and comparison with standard electroanatomic mapping
AU - Oduneye, Samuel O.
AU - Biswas, Labonny
AU - Ghate, Sudip
AU - Ramanan, Venkat
AU - Barry, Jennifer
AU - Laish-Farkash, Avishag
AU - Kadmon, Ehud
AU - Zeidan Shwiri, Tawfiq
AU - Crystal, Eugene
AU - Wright, Graham A.
N1 - Funding Information:
Manuscript received August 19, 2011; revised October 24, 2011; accepted October 25, 2011. Date of publication November 04, 2011; date of current version April 04, 2012. This work was supported by the Canadian Institutes of Health Research and the Ontario Research Fund. Asterisk indicates corresponding author. *S. O. Oduneye is with the Imaging Research, Sunnybrook Research Institute, Toronto, ON, M4N 3M5 Canada, and also with the Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9 Canada (e-mail: [email protected]).
PY - 2012/4/1
Y1 - 2012/4/1
N2 - The introduction of electroanatomic mapping (EAM) has improved the understanding of the substrate of ventricular tachycardia. EAM systems are used to delineate scar regions responsible for the arrhythmia by creating voltage or activation time maps. Previous studies have identified the benefits of creating MR-guided voltage maps; however, in some cases voltage maps may not identify regions of slow propagation that can cause the reentrant tachycardia. In this study, we obtained local activation time maps and analyzed propagation properties by performing MR-guided mapping of the porcine left ventricle while pacing from the right ventricle. Anatomical and myocardial late gadolinium enhancement images were used for catheter navigation and identification of scar regions. Our MR-guided mapping procedure showed qualitative correspondence to conventional clinical EAM systems in healthy pigs and demonstrated altered propagation in endocardial infarct models.
AB - The introduction of electroanatomic mapping (EAM) has improved the understanding of the substrate of ventricular tachycardia. EAM systems are used to delineate scar regions responsible for the arrhythmia by creating voltage or activation time maps. Previous studies have identified the benefits of creating MR-guided voltage maps; however, in some cases voltage maps may not identify regions of slow propagation that can cause the reentrant tachycardia. In this study, we obtained local activation time maps and analyzed propagation properties by performing MR-guided mapping of the porcine left ventricle while pacing from the right ventricle. Anatomical and myocardial late gadolinium enhancement images were used for catheter navigation and identification of scar regions. Our MR-guided mapping procedure showed qualitative correspondence to conventional clinical EAM systems in healthy pigs and demonstrated altered propagation in endocardial infarct models.
KW - Electrophysiology
KW - image-guided treatment
KW - magnetic resonance imaging (MRI)
UR - http://www.scopus.com/inward/record.url?scp=84859739747&partnerID=8YFLogxK
U2 - 10.1109/TMI.2011.2174645
DO - 10.1109/TMI.2011.2174645
M3 - Article
C2 - 22067265
AN - SCOPUS:84859739747
SN - 0278-0062
VL - 31
SP - 977
EP - 983
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 4
M1 - 6069862
ER -