The founder mutations in the BRCA1, BRCA2, and ATM genes in Moroccan Jewish women with breast cancer

Y. Kreiss, F. Barak, R. G. Baruch, E. Levy-Lahad, E. Pras, E. Friedman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

To gain insight into the molecular mechanisms underlying the inherited predisposition to breast cancer in non-Ashkenazi Jews, we genotyped 54 Jewish Moroccan women with breast cancer, unselected for family history of cancer, for the predominant Jewish mutations in BRCA1, BRCA2, and ATM. One patient (2%) was found to have the 185delAG BRCA1 mutation, none was a carrier of the 6174delT BRCA2 mutation, and 2/54 (4%) were heterozygous for the ATM mutation. These rates were not significantly different from the rates in the general non-Ashkenazi population. These preliminary data may indicate that the predominant Jewish mutations in BRCA1, BRCA2, and ATM genes contribute little, if any, to breast cancer predisposition and risk among Moroccan Jews.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalGenetic Testing
Volume4
Issue number4
DOIs
StatePublished - 1 Dec 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics(clinical)

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