The functional role of Nudt2 in human triple negative breast cancer

Rasha Abu-Rahmah; Hovav Nechushtan; Sanaa Hidmi; Amichay Meirovitz; Ehud Razin; Tamar Peretz

doi:10.3389/fonc.2024.1364663

The functional role of Nudt2 in human triple negative breast cancer

Rasha Abu-Rahmah, Hovav Nechushtan, Sanaa Hidmi, Amichay Meirovitz, Ehud Razin, Tamar Peretz

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.

Original language	English
Article number	1364663
Journal	Frontiers in Oncology
Volume	14
DOIs	https://doi.org/10.3389/fonc.2024.1364663
State	Published - 1 Jan 2024

Keywords

Anchorage-independent growth
NUDT2
invasion
migration
triple negative breast cancer (TNBC)

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3389/fonc.2024.1364663

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title = "The functional role of Nudt2 in human triple negative breast cancer",

abstract = "The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5{\textquoteright}, 5{\textquoteright}{\textquoteright}{\textquoteright}-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.",

keywords = "Anchorage-independent growth, NUDT2, invasion, migration, triple negative breast cancer (TNBC)",

author = "Rasha Abu-Rahmah and Hovav Nechushtan and Sanaa Hidmi and Amichay Meirovitz and Ehud Razin and Tamar Peretz",

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AU - Abu-Rahmah, Rasha

AU - Nechushtan, Hovav

AU - Hidmi, Sanaa

AU - Meirovitz, Amichay

AU - Razin, Ehud

AU - Peretz, Tamar

PY - 2024/1/1

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N2 - The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.

AB - The main known function of Nudix hydrolase 2 (Nudt2) is to hydrolyze the secondary messenger diadenosine 5’, 5’’’-p1, p4-tetraphosphate (Ap4A). In this study we examined the role of Nudt2 in breast carcinoma through its expression in human invasive ductal carcinoma tissues, and its functions in human triple negative breast cancer (TNBC) cell lines. A significantly higher expression of Nudt2 was observed in human invasive ductal carcinoma tissues compared to that in normal breast tissue. Knockdown of Nudt2 in TNBC cell lines resulted in a significant reduction in cellular proliferation via the Ki67 marker, accompanied by G0/G1 phase cell cycle arrest, in the migration and invasion of these cells and in tumorigenicity and anchorage-independent growth. It can therefore be concluded that Nudt2 plays a significant role in promoting TNBC growth.

KW - Anchorage-independent growth

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KW - invasion

KW - migration

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JO - Frontiers in Oncology

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The functional role of Nudt2 in human triple negative breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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