The HIV-1 capsid and reverse transcription

Christopher Aiken, Itay Rousso

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. Reverse transcription results in marked changes in the biophysical properties of the capsid, ultimately resulting in its breakage and disassembly. Here we review the research leading to these advances and describe hypotheses for capsid-dependent HIV-1 reverse transcription and a model for reverse transcription-primed HIV-1 uncoating.

Original languageEnglish
Article number29
Issue number1
StatePublished - 1 Dec 2021


  • Capsid
  • HIV-1
  • IP6
  • Reverse transcription
  • Stiffness
  • Uncoating

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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