The "human Cli-Knowme" Project: Building a universal, formal, procedural and declarative clinical knowledge base, for the automation of therapy and research

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

Currently, most clinical knowledge is in free text and is not easily accessible to clinicians and medical researchers. A major grand challenge for medical informatics is the creation of a distributed, universal, formal, sharable, reusable, and computationally accessible medical knowledge base. The required knowledge consists of both procedural knowledge, such as clinical guidelines, and declarative knowledge, such as context-sensitive interpretations of longitudinal patterns of raw clinical data accumulating from several sources. In this position paper, I first demonstrate the feasibility of such an enterprise, and explain in detail the overall lifecycle of a clinical guideline, by reviewing the main current components and their respective evaluations of one such comprehensive architecture for management of clinical guidelines: The Digital Electronic Guideline Library (DeGeL), a Web-based, modular, distributed architecture that facilitates gradual conversion of clinical guidelines from text to a formal representation in chosen target guideline ontology. The architecture supports guideline classification, semantic markup, context-sensitive search, browsing, run-time application to a specific patient at the point of care, and retrospective quality assessment. The DeGeL architecture operates closely with a declarative-knowledge temporal-abstraction architecture, IDAN. Thus, there is significant evidence that building a distributed, multiple-ontology architecture that caters for the full life cycle of a significant portion of current clinical procedural and declarative knowledge, which I refer to as "the Human Clin-knowme Project," has become a feasible task for a joint, coordinated, international effort involving clinicians and medical informaticians.

Original languageEnglish
Title of host publicationKnowledge Representation for Health-Care - AIME 2011 Workshop KR4HC 2011, Revised Selected Papers
Pages1-22
Number of pages22
DOIs
StatePublished - 8 Mar 2012
Event3rd International Workshop on Knowledge Representation for Health Care, KR4HC 2011, Held in Conjunction with the 13th Conference on Artificial Intelligence in Medicine, AIME 2011 - Bled, Slovenia
Duration: 6 Jul 20116 Jul 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6924 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference3rd International Workshop on Knowledge Representation for Health Care, KR4HC 2011, Held in Conjunction with the 13th Conference on Artificial Intelligence in Medicine, AIME 2011
Country/TerritorySlovenia
CityBled
Period6/07/116/07/11

Keywords

  • Automatic Application
  • Clinical Guidelines
  • Knowledge Acquisition
  • Medical Decision Support Systems
  • knowledge Representation

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science (all)

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