The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD

Carmit Netanel, David Goitein, Moshe Rubin, Yeruham Kleinbaum, Sima Katsherginsky, Hila Hermon, Keren Tsaraf, Irina Tachlytski, Amir Herman, Michal Safran, Ziv Ben-Ari

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Background: Nonalcoholic fatty liver disease (NAFLD) is common in bariatric surgery candidates. We evaluated the effect of sleeve gastrectomy (SG) on NAFLD using validated non-invasive measures. Methods: Patients with morbid obesity and NAFLD, planned for SG, were evaluated before and after surgery. Data collected included anthropometrics, biochemistry, adiponectin, SteatoTest™, NashTest™, FibroTest™, OWLiver® test and real-time ShearWave™ elastography (SWE). Results: Twenty-six subjects were included in the study, mean age 44.1 ± 4.8 years, 69.2% males. One year following SG, body mass index decreased significantly from 41.7 ± 4.8 kg/m2 to 29.6 ± 4.5 kg/m2. Concomitantly, significant improvements in triglycerides, ALT, diabetes markers and adiponectin were observed. Mean steatosis, as measured by SteatoTest™, was significantly improved. Steatohepatitis score measured by NashTest™ and OWLiver® significantly decreased. Mean fibrosis, as measured by SWE liver stiffness and FibroTest™, did not change over time. Conclusion: Steatosis and steatohepatitis are significantly improved by SG as measured by non-invasive measures.

    Original languageEnglish
    Pages (from-to)214-219
    Number of pages6
    JournalAmerican Journal of Surgery
    Volume222
    Issue number1
    DOIs
    StatePublished - 1 Jul 2021

    Keywords

    • Bariatric surgery
    • Non-invasive tests
    • Nonalcoholic fatty liver disease
    • Nonalcoholic-steatohepatitis
    • Steatosis

    Fingerprint

    Dive into the research topics of 'The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests: Impact of bariatric surgery on NAFLD'. Together they form a unique fingerprint.

    Cite this