The importance of microjet vs shock wave formation in sonophoresis

Lior Wolloch, Joseph Kost

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalJournal of Controlled Release
Volume148
Issue number2
DOIs
StatePublished - 1 Dec 2010

Keywords

  • Cavitations
  • Microjets
  • Shock waves
  • Sonophoresis
  • Transdermal
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science

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