The importance of microjet vs shock wave formation in sonophoresis

Lior Wolloch; Joseph Kost

doi:10.1016/j.jconrel.2010.07.106

The importance of microjet vs shock wave formation in sonophoresis

Lior Wolloch, Joseph Kost

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.

Original language	English
Pages (from-to)	204-211
Number of pages	8
Journal	Journal of Controlled Release
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/j.jconrel.2010.07.106
State	Published - 1 Dec 2010

Keywords

Cavitations
Microjets
Shock waves
Sonophoresis
Transdermal
Ultrasound

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2010.07.106

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abstract = "Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.",

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AB - Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.

KW - Cavitations

KW - Microjets

KW - Shock waves

KW - Sonophoresis

KW - Transdermal

KW - Ultrasound

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ER -

The importance of microjet vs shock wave formation in sonophoresis

Abstract

Keywords

ASJC Scopus subject areas

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