The induction of virus-specific CTL as a function of increasing epitope expression: Responses rise steadily until excessively high levels of epitope are attained

E. John Wherry, Kristin A. Puorro, Angel Porgador, Laurence C. Eisenlohr

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The role of epitope expression levels in CD8+ T cell priming has been controversial. Yet this parameter is of great importance in the design of rational approaches to optimize CTL responses to a variety of pathogens. In this paper we examine the influence of epitope production on CD8+ T cell priming by exploiting a system that allows a 200-fold range of cell surface epitope expression in vitro with a fixed dose of vaccinia virus. Our results demonstrate that, with the exception of a notable decline at the highest level of epitope, the magnitude of the responding CTL population generated in vivo following equivalent viral infections is essentially proportional to epitope density.

Original languageEnglish
Pages (from-to)3735-3745
Number of pages11
JournalJournal of Immunology
Volume163
Issue number7
StatePublished - 1 Oct 1999

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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