TY - JOUR
T1 - The influence of age and sex on blood levels of calcium-regulating hormones in dogs
AU - Meller, Y.
AU - Kestenbaum, R. S.
AU - Yagil, R.
AU - Shany, S.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - In order to study age- and sex-related changes in calcium-regulating hormones, serum levels of parathormone (PTH), calcitonin (CT), and vitamin D metabolites were determined in 20 young dogs and 11 old dogs. A highly significant increase in serum levels of PTH was observed in old dogs (1.65 ± 0.09 ng/ml versus 1.05 ± 0.09 ng/ml in young animals) (p<0.001). Serum levels of 25-(OH)-D were significantly decreased in old dogs (11.24 ± 203 ng/ml compared to 20.59 ± 1.57 ng/ml in young dogs) (p<0.001). No significant differences in serum levels of 1,25-(OH)2-D, 24,25-(OH)2-D, and CT were found between young and old dogs. Serum CT levels were higher in males, especially in old animals. Young females had significantly higher serum levels of 25-(OH)-D than males. It seems that for some reason old dogs are in a relative state of vitamin D deficiency and hyperparathyroidism, which suggests the cause of skeletal alterations related to aging. A similar situation is observed in human geriatric patients.
AB - In order to study age- and sex-related changes in calcium-regulating hormones, serum levels of parathormone (PTH), calcitonin (CT), and vitamin D metabolites were determined in 20 young dogs and 11 old dogs. A highly significant increase in serum levels of PTH was observed in old dogs (1.65 ± 0.09 ng/ml versus 1.05 ± 0.09 ng/ml in young animals) (p<0.001). Serum levels of 25-(OH)-D were significantly decreased in old dogs (11.24 ± 203 ng/ml compared to 20.59 ± 1.57 ng/ml in young dogs) (p<0.001). No significant differences in serum levels of 1,25-(OH)2-D, 24,25-(OH)2-D, and CT were found between young and old dogs. Serum CT levels were higher in males, especially in old animals. Young females had significantly higher serum levels of 25-(OH)-D than males. It seems that for some reason old dogs are in a relative state of vitamin D deficiency and hyperparathyroidism, which suggests the cause of skeletal alterations related to aging. A similar situation is observed in human geriatric patients.
UR - http://www.scopus.com/inward/record.url?scp=0021206591&partnerID=8YFLogxK
U2 - 10.1097/00003086-198407000-00045
DO - 10.1097/00003086-198407000-00045
M3 - Article
AN - SCOPUS:0021206591
SN - 0009-921X
VL - 187
SP - 296
EP - 299
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
ER -