The influence of early diagnosis of endometrioid endometrial cancer on disease stage and survival

Frida Barak, Leonid Kalichman, Michael Gdalevich, Ronny Milgrom, Yael Laitman, Benjamin Piura, Ofer Lavie, Ofer Gemer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To evaluate whether the presence or duration of uterine bleeding is associated with disease stage, and survival of patients with endometrioid endometrial carcinoma (EEC). Methods: The records of 220 patients with EEC who underwent surgery were reviewed. The patients were divided into three groups according to the presence and duration of vaginal bleeding at the time of surgery. Group 1, without vaginal bleeding; group 2, vaginal bleeding up to 3 months; group 3, vaginal bleeding exceeding 3 months prior to surgery. Disease stage and survival were between the three groups. Results: Of the 220 patients, 42 (19 %) were asymptomatic; 95 (43 %) had symptom duration of up to 3 months and 83 (38 %) experienced bleeding for >3 months. There were no significant differences between groups 1, 2 and 3 regarding the proportion of patients with deep invasion in stage I (21, 24, 26 %, p = 0.84; respectively), with grade 3 tumors (10, 13, 14 %, p = 0.42; respectively) or with advanced stage disease (12, 14, 15 %, p = 0.92; respectively). Survival analysis demonstrated a non-significant trend toward better survival in asymptomatic patients and in patients with a shorter duration of symptoms (p = 0.172). Conclusions: Diagnosis of EEC in asymptomatic patients or in patients with a short duration of bleeding is associated with comparable stage and survival.

Original languageEnglish
Pages (from-to)1361-1364
Number of pages4
JournalArchives of Gynecology and Obstetrics
Issue number6
StatePublished - 1 Dec 2013


  • Bleeding
  • Endometrial cancer
  • Survival

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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