TY - GEN
T1 - The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in remodeling atrial tachycardia
AU - Beharier, Ofer
AU - Etzion, Yoram
AU - Levi, Shiri
AU - Mor, Merav
AU - Mor, Michal
AU - Dror, Shani
AU - Kahn, Joy
AU - Katz, Amos
AU - Moran, Arie
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Atrial fibrillation (AF), the highest occurring cardiac arrhythmia in the Western world, is associated with substantial morbidity and increased mortality. In spite of extensive research, the cause of atrial electrical remodeling, a major factor in the self-perpetuating nature of AF, is still unknown. Downregulation of L-type Ca2+ channel (LTCC) activity is the hallmark of atrial electrical remodeling. ZnT-1 is a ubiquitous membrane protein that was recently suggested to inhibit the LTCC. We have studied and shown that ZnT-1 expression inhibits LTCC function in an oocyte expression system as well as in isolated cardiomyocytes. Our data also show that rapid electrical pacing can augment ZnT-1 expression in culture as well as in the atria of rats in vivo. Finally, in a pilot study, ZnT-1 expression was found to be augmented in the atria of AF patients. These findings position ZnT-1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling.
AB - Atrial fibrillation (AF), the highest occurring cardiac arrhythmia in the Western world, is associated with substantial morbidity and increased mortality. In spite of extensive research, the cause of atrial electrical remodeling, a major factor in the self-perpetuating nature of AF, is still unknown. Downregulation of L-type Ca2+ channel (LTCC) activity is the hallmark of atrial electrical remodeling. ZnT-1 is a ubiquitous membrane protein that was recently suggested to inhibit the LTCC. We have studied and shown that ZnT-1 expression inhibits LTCC function in an oocyte expression system as well as in isolated cardiomyocytes. Our data also show that rapid electrical pacing can augment ZnT-1 expression in culture as well as in the atria of rats in vivo. Finally, in a pilot study, ZnT-1 expression was found to be augmented in the atria of AF patients. These findings position ZnT-1 as a probable missing link in the mechanism underlying atrial tachycardia remodeling.
KW - Atrial electrical remodeling
KW - Atrial fibrillation
KW - Cation diffusion facilitator proteins
KW - L-type calcium channels
KW - Rapid pacing
KW - ZnT-1
UR - http://www.scopus.com/inward/record.url?scp=77649091131&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05087.x
DO - 10.1111/j.1749-6632.2009.05087.x
M3 - Conference contribution
C2 - 20201890
AN - SCOPUS:77649091131
SN - 9781573317474
T3 - Annals of the New York Academy of Sciences
SP - 87
EP - 95
BT - Analysis of Cardiac Development
PB - Blackwell Publishing Inc.
ER -