The life cycle of the 26S proteasome: From birth, through regulation and function, and onto its death

Ido Livneh; Victoria Cohen-Kaplan; Chen Cohen-Rosenzweig; Noa Avni; Aaron Ciechanover

doi:10.1038/cr.2016.86

The life cycle of the 26S proteasome: From birth, through regulation and function, and onto its death

Ido Livneh, Victoria Cohen-Kaplan, Chen Cohen-Rosenzweig, Noa Avni, Aaron Ciechanover

Research output: Contribution to journal › Review article › peer-review

237 Scopus citations

Abstract

The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

Original language	English
Pages (from-to)	869-885
Number of pages	17
Journal	Cell Research
Volume	26
Issue number	8
DOIs	https://doi.org/10.1038/cr.2016.86
State	Published - 1 Aug 2016
Externally published	Yes

Keywords

proteasome
ubiquitin

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/cr.2016.86

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abstract = "The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.",

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AU - Avni, Noa

AU - Ciechanover, Aaron

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AB - The 26S proteasome is a large, ∼2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated degradation of cytosolic, nuclear and membrane proteins in all eukaryotic organisms.

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The life cycle of the 26S proteasome: From birth, through regulation and function, and onto its death

Abstract

Keywords

ASJC Scopus subject areas

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