The Medial Prefrontal Cortex and Integration in Autism

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55 Scopus citations


This article offers a unifying theoretical interpretation of known abnormalities in people with autism spectrum disorders (ASDs) in four psychological domains, namely emotion, memory, sensation-perception, and motor skills. It proposes that in all four domains three levels of processing can be identified: a basic level, an integrative level, and a "logical" or higher-order level. It also notes that in typically developing people, there is evidence that the integrative level is subserved by subregions of the medial prefrontal cortex. The major argument of the article is to propose and argue that the integrative level in all four domains is responsible for common atypicalities in people with ASDs.

Original languageEnglish
Pages (from-to)589-598
Number of pages10
Issue number6
StatePublished - 2009


  • Autism
  • Emotion
  • Integration
  • Medial prefrontal
  • Memory


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