The membrane: Transertion as an organizing principle in membrane heterogeneity

Kouji Matsumoto, Hiroshi Hara, Itzhak Fishov, Eugenia Mileykovskaya, Vic Norris

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The bacterial membrane exhibits a significantly heterogeneous distribution of lipids and proteins. This heterogeneity results mainly from lipid-lipid, protein-protein, and lipid-protein associations which are orchestrated by the coupled transcription, translation and insertion of nascent proteins into and through membrane (transertion). Transertion is central not only to the individual assembly and disassembly of large physically linked groups of macromolecules (alias hyperstructures) but also to the interactions between these hyperstructures. We review here these interactions in the context of the processes in Bacillus subtilis and Escherichia coli of nutrient sensing, membrane synthesis, cytoskeletal dynamics, DNA replication, chromosome segregation, and cell division.

Original languageEnglish
Article number572
JournalFrontiers in Microbiology
Volume6
Issue numberJUN
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Bacillus subtilis
  • Escherichia coli
  • Hyperstructures
  • Lipid domain
  • Membrane
  • Transertion

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