The myofibroblast at a glance

Pardis Pakshir, Nina Noskovicova, Monika Lodyga, Dong Ok Son, Ronen Schuster, Amanda Goodwin, Henna Karvonen, Boris Hinz

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

In 1971, Gabbiani and co-workers discovered and characterized the modification of fibroblasts into cells which are capable of an active spasm (contraction) in rat wound granulation tissue and, accordingly, named these cells 'myofibroblasts'. Now, myofibroblasts are not only recognized for their physiological role in tissue repair but also as cells that are key in promoting the development of fibrosis in all organs. In this Cell Science at a Glance and the accompanying poster, we provide an overview of the current understanding of central aspects of myofibroblast biology, such as their definition, activation from different precursors, the involved signaling pathways and most widely used models to study their function.Myofibroblastswill be placed into context with their extracellularmatrix and with other cell types communicating in the fibrotic environment. Furthermore, the challenges and strategies to target myofibroblasts in anti-fibrotic therapies are summarized to emphasize their crucial role in disease progression.

Original languageEnglish
Article numberjcs227900
JournalJournal of Cell Science
Volume133
Issue number13
DOIs
StatePublished - 10 Jul 2020
Externally publishedYes

Keywords

  • Fibrosis
  • Growth factor activation
  • Tissue repair
  • Wound healing

ASJC Scopus subject areas

  • Cell Biology

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