The myths surrounding mild stimulation in vitro fertilization (IVF)

Raoul Orvieto; Valeria Stella Vanni; Norbert Gleicher

doi:10.1186/s12958-017-0266-1

The myths surrounding mild stimulation in vitro fertilization (IVF)

Raoul Orvieto, Valeria Stella Vanni, Norbert Gleicher

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.

Original language	English
Article number	48
Journal	Reproductive Biology and Endocrinology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s12958-017-0266-1
State	Published - 24 Jun 2017
Externally published	Yes

Keywords

Aneuploidy
Cost-effectiveness
In vitro fertilization (IVF)
Live birth rates
Ovarian hyperstimulation syndrome (OHSS)
Ovarian stimulation
Pregnancy rates

ASJC Scopus subject areas

Reproductive Medicine
Endocrinology
Obstetrics and Gynecology
Developmental Biology

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10.1186/s12958-017-0266-1

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title = "The myths surrounding mild stimulation in vitro fertilization (IVF)",

abstract = "So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.",

keywords = "Aneuploidy, Cost-effectiveness, In vitro fertilization (IVF), Live birth rates, Ovarian hyperstimulation syndrome (OHSS), Ovarian stimulation, Pregnancy rates",

author = "Raoul Orvieto and Vanni, {Valeria Stella} and Norbert Gleicher",

note = "Funding Information: The authors would like to thank the {\textquoteleft}Memorial Fund Griffini Miglierina{\textquoteright} within the {\textquoteleft}Fondazione Comunitaria del Varesotto Onlus{\textquoteright} for non-restricted financial support to Dr. VSV during the completion of the study. Publisher Copyright: {\textcopyright} 2017 The Author(s).",

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T1 - The myths surrounding mild stimulation in vitro fertilization (IVF)

AU - Orvieto, Raoul

AU - Vanni, Valeria Stella

AU - Gleicher, Norbert

N1 - Funding Information: The authors would like to thank the ‘Memorial Fund Griffini Miglierina’ within the ‘Fondazione Comunitaria del Varesotto Onlus’ for non-restricted financial support to Dr. VSV during the completion of the study. Publisher Copyright: © 2017 The Author(s).

PY - 2017/6/24

Y1 - 2017/6/24

N2 - So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.

AB - So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost. We conclude that an objective review of the literature does not support the routine utilization of mCOH in assisted reproduction.

KW - Aneuploidy

KW - Cost-effectiveness

KW - In vitro fertilization (IVF)

KW - Live birth rates

KW - Ovarian hyperstimulation syndrome (OHSS)

KW - Ovarian stimulation

KW - Pregnancy rates

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U2 - 10.1186/s12958-017-0266-1

DO - 10.1186/s12958-017-0266-1

M3 - Review article

AN - SCOPUS:85021188320

VL - 15

JO - Reproductive Biology and Endocrinology

JF - Reproductive Biology and Endocrinology

SN - 1477-7827

IS - 1

M1 - 48

ER -

The myths surrounding mild stimulation in vitro fertilization (IVF)

Abstract

Keywords

ASJC Scopus subject areas

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