TY - JOUR
T1 - The neurophysiology and pathology of brain zinc
AU - Sensi, Stefano L.
AU - Paoletti, Pierre
AU - Koh, Jae Young
AU - Aizenman, Elias
AU - Bush, Ashley I.
AU - Hershfinkel, Michal
PY - 2011/11/9
Y1 - 2011/11/9
N2 - Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.
AB - Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=80755181339&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.3454-11.2011
DO - 10.1523/JNEUROSCI.3454-11.2011
M3 - Article
C2 - 22072659
AN - SCOPUS:80755181339
SN - 0270-6474
VL - 31
SP - 16076
EP - 16085
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 45
ER -
