The neurophysiology and pathology of brain zinc

Stefano L. Sensi, Pierre Paoletti, Jae Young Koh, Elias Aizenman, Ashley I. Bush, Michal Hershfinkel

    Research output: Contribution to journalArticlepeer-review

    278 Scopus citations

    Abstract

    Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability of genetically modified animal models, selective zinc-sensitive fluorescent probes, and novel chelators is producing a remarkable body of exciting new data that clearly establishes this metal ion as a key modulator of intracellular and intercellular neuronal signaling. In this Mini-Symposium, we will review and discuss the most recent findings that link zinc to synaptic function as well as the injurious effects of zinc dyshomeostasis within the context of neuronal death associated with major human neurological disorders, including stroke, epilepsy, and Alzheimer's disease.

    Original languageEnglish
    Pages (from-to)16076-16085
    Number of pages10
    JournalJournal of Neuroscience
    Volume31
    Issue number45
    DOIs
    StatePublished - 9 Nov 2011

    ASJC Scopus subject areas

    • General Neuroscience

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