The physiologic and therapeutic role of heparin in implantation and placentation

Michela Quaranta, Offer Erez, Salvatore Andrea Mastrolia, Arie Koifman, Elad Leron, Tamar Eshkoli, Moshe Mazor, Gershon Holcberg

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, pretermlabor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.

Original languageEnglish
Article numbere691
Issue number1
StatePublished - 1 Jan 2015
Externally publishedYes


  • Cadherins
  • Glycosaminoglycan
  • HB-EGF
  • Immune system
  • Matrix metalloproteinases
  • Selectins
  • Trophoblast

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


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