Abstract
Implantation, trophoblast development and placentation are crucial processes in the establishment and development of normal pregnancy. Abnormalities of these processes can lead to pregnancy complications known as the great obstetrical syndromes: preeclampsia, intrauterine growth restriction, fetal demise, premature prelabor rupture of membranes, pretermlabor, and recurrent pregnancy loss. There is mounting evidence regarding the physiological and therapeutic role of heparins in the establishment of normal gestation and as a modality for treatment and prevention of pregnancy complications. In this review, we will summarize the properties and the physiological contributions of heparins to the success of implantation, placentation and normal pregnancy.
Original language | English |
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Article number | e691 |
Journal | PeerJ |
Volume | 2015 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2015 |
Keywords
- Cadherins
- Glycosaminoglycan
- HB-EGF
- Immune system
- Matrix metalloproteinases
- Selectins
- Trophoblast
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- General Agricultural and Biological Sciences