The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus

Venu Gopal Jonnalagadda, Allam Venkata Sita Ram Raju, Srinivas Pittala, Afsar shaik, Nilakash Annaji Selkar

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Metabolic disorders are a group of disorders, due to the disruption of the normal metabolic process at a cellular level. Diabetes Mellitus and Tyrosinaemia are the majorly reported metabolic disorders. Among them, Diabetes Mellitus is a one of the leading metabolic syndrome, affecting 5 to 7 % of the population worldwide and mainly characterised by elevated levels of glucose and is associated with two types of physiological event disturbances such as impaired insulin secretion and insulin resistance. Up to now, various treatment strategies are like insulin, alphaglucosidase inhibitors, biguanides, incretins were being followed. Concurrently, various novel therapeutic strategies are required to advance the therapy of Diabetes mellitus. For the last few decades, there has been an extensive research in understanding the metabolic pathways involved in Diabetes Mellitus at the cellular level and having the profound knowledge on cell-growth, cell-cycle, and apoptosis at a molecular level provides new targets for the treatment of Diabetes Mellitus. Receptor signalling has been involved in these mechanisms, to translate the information coming from outside. To understand the various receptors involved in these pathways, we must have a sound knowledge on receptors and ligands involved in it. This review mainly summarises the receptors and ligands which are involved the Diabetes Mellitus. Finally, researchers have to develop the alternative chemical moieties that retain their affinity to receptors and efficacy. Diabetes Mellitus being a metabolic disorder due to the glucose surfeit, demands the need for regular exercise along with dietary changes.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalAdvanced Pharmaceutical Bulletin
Volume4
Issue number3
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Ligands
  • Receptors
  • Signalling

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology, Toxicology and Pharmaceutics (all)

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