The preterm parturition syndrome

R. Romero, J. Espinoza, J. P. Kusanovic, F. Gotsch, S. Hassan, O. Erez, T. Chaiworapongsa, M. Mazor

    Research output: Contribution to journalReview articlepeer-review

    1008 Scopus citations


    The implicit paradigm that has governed the study and clinical management of preterm labour is that term and preterm parturition are the same processes, except for the gestational age at which they occur. Indeed, both share a common pathway composed of uterine contractility, cervical dilatation and activation of the membranes/decidua. This review explores the concept that while term labour results from physiological activation of the components of the common pathway, preterm labour arises from pathological signalling and activation of one or more components of the common pathway of parturition. The term 'great obstetrical syndromes' has been coined to reframe the concept of obstetrical disease. Such syndromes are characterised by: (1) multiple aetiology; (2) long preclinical stage; (3) frequent fetal involvement; (4) clinical manifestations that are often adaptive in nature; and (5) gene-environment interactions that may predispose to the syndromes. This article reviews the evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: (1) intrauterine infection/inflammation; (2) uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin-releasing factor related). The implications of this conceptual framework for the prevention, diagnosis, and treatment of preterm labour are discussed.

    Original languageEnglish
    Pages (from-to)17-42
    Number of pages26
    JournalBJOG: An International Journal of Obstetrics and Gynaecology
    Issue numberSUPPL. 3
    StatePublished - 1 Dec 2006


    • Allergy
    • Cervical insufficiency
    • Inflammation
    • Intrauterine infection
    • Multiple aetiology
    • Prematurity
    • Preterm birth
    • Preterm labour
    • Uterine ischaemia
    • Uterine overdistension

    ASJC Scopus subject areas

    • Obstetrics and Gynecology


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