The prevalence of gastroesophageal reflux in children with tracheomalacia and laryngomalacia

Haim Bibi, Ekaterina Khvolis, David Shoseyov, Melly Ohaly, David Ben Dor, Daniel London, Dorit Ater

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Objective: We conducted a retrospective study to determine the relationship between gastroesophageal reflux (GER) and large airways malacia in infancy. Methods: One hundred sixteen children referred for chronic respiratory problems who were between the ages of 3 and 28 months were investigated. All of them underwent flexible bronchoscopy and chest radiography. Eighteen children had laryngomalacia, 13 had tracheomalacia, and 23 had combined laryngotracheomalacia. During bronchoscopy, BAL was performed. An analysis of macrophages in the BAL fluid for lipid content was performed. Fifty-four children with laryngomalacia and tracheomalacia constituted the study group, and 62 children were in the control group. Reflux studies were obtained for 40 children from the study group and 41 from the control group. Results: In the study group, 28 children (70%) had GER documented by reflux studies compared with 16 children (39%) in the control group (p < 0.01). In the control group, GER was found mainly among those with recurrent bilateral pneumonia. The lipid-laden macrophage score was correlated with the documented GER. Conclusion: GER is prevalent among infants with large airways malacia, and treatment of this group with antireflux therapy should be considered.

Original languageEnglish
Pages (from-to)409-413
Number of pages5
Issue number2
StatePublished - 1 Jan 2001
Externally publishedYes


  • Gastroesophageal reflux
  • Laryngomalacia
  • Tracheomalacia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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