The prognostic role of neutrophil-to-lymphocyte ratio in patients hospitalized with acute pulmonary embolism

Orly Efros, Tal Beit Halevi, Eshcar Meisel, Shelly Soffer, Noam Barda, Omri Cohen, Gili Kenet, Aharon Lubetsky

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Early risk stratification is essential for determining the appropriate therapeutic management approach of pulmonary embolism (PE). This study aimed to evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients hospitalized with acute pulmonary embolism by investigating its association with mortality in a large-scale population diagnosed and hospitalized with acute PE. We retrieved all consecutive patients hospitalized in an internal medicine department or an intensive care unit in a tertiary medical center from December 2007 to April 2021 with a discharge diagnosis of pulmonary embolism. A total of 2068 patients were included. Patients with above-median NLR (i.e., 5.12) had a higher 30-day mortality risk (adjusted odds ratio (aOR), 2.82; 95% confidence interval (CI) 2.14–3.70) and higher one-year mortality risk (aOR, 2.51; 95% CI 2.04–3.08). Similar trends were demonstrated in a sub-analysis of patients without cancer and hemodynamically stable (i.e., systolic blood pressure over 90 mmHg). Furthermore, the median hospital length of stay in patients with an elevated NLR was higher, and so was the in-hospital mortality rate. Elevated NLR in acute PE is associated with a worse short-term and long-term prognosis and with a longer duration of hospitalization.

Original languageEnglish
Article number4058
JournalJournal of Clinical Medicine
Volume10
Issue number18
DOIs
StatePublished - 1 Sep 2021
Externally publishedYes

Keywords

  • Neutrophil-to-lymphocyte ratio (NLR)
  • Pulmonary embolism (PE)
  • Venous thromboem-bolism (VTE)

ASJC Scopus subject areas

  • General Medicine

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