The regioselective coupling of 2-arylquinazolinone C-H with aldehydes and benzyl alcohols under oxidative conditions

Umesh A. Kshirsagar; Deepali S. Waghmare; Shrikant D. Tambe

doi:10.1039/d0nj03721d

The regioselective coupling of 2-arylquinazolinone C-H with aldehydes and benzyl alcohols under oxidative conditions

Umesh A. Kshirsagar, Deepali S. Waghmare, Shrikant D. Tambe

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The direct and regioselective palladium-catalyzed dehydrogenative coupling of aldehydes and benzyl alcohols with 2-aryl-quinazolinone C-H endowed with a quinazolinone nucleus, which is one of the most fascinating and vital core units, as an inherent directing group under oxidative conditions was developed. This atom/step economic aroylation offers an attractive handle and a very green approach for highly convergent and diversity-oriented synthetic modifications and the construction of vital molecules of therapeutic interest.

Original language	English
Pages (from-to)	16697-16701
Number of pages	5
Journal	New Journal of Chemistry
Volume	44
Issue number	39
DOIs	https://doi.org/10.1039/d0nj03721d
State	Published - 21 Oct 2020
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Materials Chemistry

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abstract = "The direct and regioselective palladium-catalyzed dehydrogenative coupling of aldehydes and benzyl alcohols with 2-aryl-quinazolinone C-H endowed with a quinazolinone nucleus, which is one of the most fascinating and vital core units, as an inherent directing group under oxidative conditions was developed. This atom/step economic aroylation offers an attractive handle and a very green approach for highly convergent and diversity-oriented synthetic modifications and the construction of vital molecules of therapeutic interest.",

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AU - Tambe, Shrikant D.

PY - 2020/10/21

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AB - The direct and regioselective palladium-catalyzed dehydrogenative coupling of aldehydes and benzyl alcohols with 2-aryl-quinazolinone C-H endowed with a quinazolinone nucleus, which is one of the most fascinating and vital core units, as an inherent directing group under oxidative conditions was developed. This atom/step economic aroylation offers an attractive handle and a very green approach for highly convergent and diversity-oriented synthetic modifications and the construction of vital molecules of therapeutic interest.

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The regioselective coupling of 2-arylquinazolinone C-H with aldehydes and benzyl alcohols under oxidative conditions

Abstract

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