The relation between psychological factors and DNA-damage: A critical review

Yori Gidron; Katie Russ; Harilaos Tissarchondou; Jane Warner

doi:10.1016/j.biopsycho.2005.11.011

The relation between psychological factors and DNA-damage: A critical review

Yori Gidron, Katie Russ, Harilaos Tissarchondou, Jane Warner

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Investigating relations between psychological factors and DNA-damage can contribute to understanding how psychological factors affect the etiology and prognosis of relevant diseases (e.g., cancer, heart disease) at the fundamental level of mutated cells. This article critically reviews 21 studies in animals and humans testing relations between psychological factors and DNA-damage. After providing a biological background, we critically review each study. The findings in humans are mapped onto a model of stress, coping and health. These studies demonstrate causal relations between acute stressors and DNA-damage in animals and significant correlations between psychological factors (e.g., depression, coping) and DNA-damage in humans, which are moderated by gender. Possible mechanisms for these relations, limitations of studies, clinical implications and suggestions for future research are provided.

Original language	English
Pages (from-to)	291-304
Number of pages	14
Journal	Biological Psychology
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsycho.2005.11.011
State	Published - 1 Jun 2006
Externally published	Yes

Keywords

DNA-damage
Disease
Gender
Psychological factors
Stress

ASJC Scopus subject areas

General Neuroscience
Neuropsychology and Physiological Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biopsycho.2005.11.011

Cite this

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AU - Russ, Katie

AU - Tissarchondou, Harilaos

AU - Warner, Jane

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AB - Investigating relations between psychological factors and DNA-damage can contribute to understanding how psychological factors affect the etiology and prognosis of relevant diseases (e.g., cancer, heart disease) at the fundamental level of mutated cells. This article critically reviews 21 studies in animals and humans testing relations between psychological factors and DNA-damage. After providing a biological background, we critically review each study. The findings in humans are mapped onto a model of stress, coping and health. These studies demonstrate causal relations between acute stressors and DNA-damage in animals and significant correlations between psychological factors (e.g., depression, coping) and DNA-damage in humans, which are moderated by gender. Possible mechanisms for these relations, limitations of studies, clinical implications and suggestions for future research are provided.

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KW - Gender

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The relation between psychological factors and DNA-damage: A critical review

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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