The relationship between hypothalamic prostaglandin E2 or leukotrienes and the body temperature response to lipopolysaccharide in different murine strains

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Abstract

1. In CD/1 and BALB/c mice, lipopolysaccharide (LPS) caused hypothermia, whereas C57BL/6 mice responded to LPS by elevation in body temperature (T(b)). 2. In CD/1 and BALB/c mice, LPS caused an increase in leukotriene (LT) production by hypothalamus, while no significant elevation in prostaglandin E2 (PGE2) production was observed. The opposite changes in hypothalamic eicosanoids were observed in LPS-treated C57BL/6 mice. 3. The results suggest that the balance between hypothalamic pyrogenic (PGE2) or cryogenic (LTs) eicosanoids may determine the strain-specific T(b) responses to LPS in mice.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalJournal of Thermal Biology
Volume25
Issue number1-2
DOIs
StatePublished - 1 Feb 2000

Keywords

  • BALB/c
  • Body temperature
  • C57BL/6 mice
  • CD/1
  • Eicosanoids
  • Fever
  • Hypothalamus
  • Hypothermia
  • Leukotrienes
  • Lipopolysaccharide
  • Prostaglandin E

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