The relationship between hypothalamic prostaglandin E2 or leukotrienes and the body temperature response to lipopolysaccharide in different murine strains

V. Fraifeld; L. Paul; J. Kaplanski

doi:10.1016/S0306-4565(99)00047-9

The relationship between hypothalamic prostaglandin E₂ or leukotrienes and the body temperature response to lipopolysaccharide in different murine strains

V. Fraifeld, L. Paul, J. Kaplanski

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

1. In CD/1 and BALB/c mice, lipopolysaccharide (LPS) caused hypothermia, whereas C57BL/6 mice responded to LPS by elevation in body temperature (T(b)). 2. In CD/1 and BALB/c mice, LPS caused an increase in leukotriene (LT) production by hypothalamus, while no significant elevation in prostaglandin E₂ (PGE₂) production was observed. The opposite changes in hypothalamic eicosanoids were observed in LPS-treated C57BL/6 mice. 3. The results suggest that the balance between hypothalamic pyrogenic (PGE₂) or cryogenic (LTs) eicosanoids may determine the strain-specific T(b) responses to LPS in mice.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Journal of Thermal Biology
Volume	25
Issue number	1-2
DOIs	https://doi.org/10.1016/S0306-4565(99)00047-9
State	Published - 1 Feb 2000

Keywords

BALB/c
Body temperature
C57BL/6 mice
CD/1
Eicosanoids
Fever
Hypothalamus
Hypothermia
Leukotrienes
Lipopolysaccharide
Prostaglandin E

ASJC Scopus subject areas

Biochemistry
Physiology
General Agricultural and Biological Sciences
Developmental Biology

Access to Document

10.1016/S0306-4565(99)00047-9

Cite this

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title = "The relationship between hypothalamic prostaglandin E2 or leukotrienes and the body temperature response to lipopolysaccharide in different murine strains",

abstract = "1. In CD/1 and BALB/c mice, lipopolysaccharide (LPS) caused hypothermia, whereas C57BL/6 mice responded to LPS by elevation in body temperature (T(b)). 2. In CD/1 and BALB/c mice, LPS caused an increase in leukotriene (LT) production by hypothalamus, while no significant elevation in prostaglandin E2 (PGE2) production was observed. The opposite changes in hypothalamic eicosanoids were observed in LPS-treated C57BL/6 mice. 3. The results suggest that the balance between hypothalamic pyrogenic (PGE2) or cryogenic (LTs) eicosanoids may determine the strain-specific T(b) responses to LPS in mice.",

keywords = "BALB/c, Body temperature, C57BL/6 mice, CD/1, Eicosanoids, Fever, Hypothalamus, Hypothermia, Leukotrienes, Lipopolysaccharide, Prostaglandin E",

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T1 - The relationship between hypothalamic prostaglandin E2 or leukotrienes and the body temperature response to lipopolysaccharide in different murine strains

AU - Fraifeld, V.

AU - Paul, L.

AU - Kaplanski, J.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - 1. In CD/1 and BALB/c mice, lipopolysaccharide (LPS) caused hypothermia, whereas C57BL/6 mice responded to LPS by elevation in body temperature (T(b)). 2. In CD/1 and BALB/c mice, LPS caused an increase in leukotriene (LT) production by hypothalamus, while no significant elevation in prostaglandin E2 (PGE2) production was observed. The opposite changes in hypothalamic eicosanoids were observed in LPS-treated C57BL/6 mice. 3. The results suggest that the balance between hypothalamic pyrogenic (PGE2) or cryogenic (LTs) eicosanoids may determine the strain-specific T(b) responses to LPS in mice.

AB - 1. In CD/1 and BALB/c mice, lipopolysaccharide (LPS) caused hypothermia, whereas C57BL/6 mice responded to LPS by elevation in body temperature (T(b)). 2. In CD/1 and BALB/c mice, LPS caused an increase in leukotriene (LT) production by hypothalamus, while no significant elevation in prostaglandin E2 (PGE2) production was observed. The opposite changes in hypothalamic eicosanoids were observed in LPS-treated C57BL/6 mice. 3. The results suggest that the balance between hypothalamic pyrogenic (PGE2) or cryogenic (LTs) eicosanoids may determine the strain-specific T(b) responses to LPS in mice.

KW - BALB/c

KW - Body temperature

KW - C57BL/6 mice

KW - CD/1

KW - Eicosanoids

KW - Fever

KW - Hypothalamus

KW - Hypothermia

KW - Leukotrienes

KW - Lipopolysaccharide

KW - Prostaglandin E

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