The reproducibility of trophectoderm biopsies – The chaos behind preimplantation genetic testing for aneuploidy

Raoul Orvieto

doi:10.1016/j.ejogrb.2020.07.052

The reproducibility of trophectoderm biopsies – The chaos behind preimplantation genetic testing for aneuploidy

Raoul Orvieto

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Chromosomal mosaicism is a common feature of early human embryos development. “Mosaic” embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.

Original language	English
Pages (from-to)	57-58
Number of pages	2
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	254
DOIs	https://doi.org/10.1016/j.ejogrb.2020.07.052
State	Published - 1 Nov 2020
Externally published	Yes

Keywords

Blastocyst
Mosaicism
PGT-A
Screening test
Trophectoderm

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.ejogrb.2020.07.052

Cite this

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abstract = "Chromosomal mosaicism is a common feature of early human embryos development. “Mosaic” embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.",

keywords = "Blastocyst, Mosaicism, PGT-A, Screening test, Trophectoderm",

author = "Raoul Orvieto",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

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N2 - Chromosomal mosaicism is a common feature of early human embryos development. “Mosaic” embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.

AB - Chromosomal mosaicism is a common feature of early human embryos development. “Mosaic” embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.

KW - Blastocyst

KW - Mosaicism

KW - PGT-A

KW - Screening test

KW - Trophectoderm

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DO - 10.1016/j.ejogrb.2020.07.052

M3 - Review article

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SN - 0301-2115

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ER -

The reproducibility of trophectoderm biopsies – The chaos behind preimplantation genetic testing for aneuploidy

Abstract

Keywords

ASJC Scopus subject areas

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