The reproducibility of trophectoderm biopsies – The chaos behind preimplantation genetic testing for aneuploidy

Raoul Orvieto

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Chromosomal mosaicism is a common feature of early human embryos development. “Mosaic” embryos display very low rates of concordance between multiple trophectoderm biopsies and between multiple trophectoderm and inner cell mass biopsies using next-generation sequencing. The here presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.

Original languageEnglish
Pages (from-to)57-58
Number of pages2
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume254
DOIs
StatePublished - 1 Nov 2020
Externally publishedYes

Keywords

  • Blastocyst
  • Mosaicism
  • PGT-A
  • Screening test
  • Trophectoderm

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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