TY - JOUR
T1 - The reproductive potential of patients with Mayer-Rokitansky-Küster-Hauser syndrome using gestational surrogacy
T2 - A systematic review
AU - Friedler, Shevach
AU - Grin, Leonti
AU - Liberti, Gad
AU - Saar-Ryss, Buzhena
AU - Rabinson, Yaakov
AU - Meltzer, Semion
N1 - Publisher Copyright:
© 2015 Reproductive Healthcare Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome may reproduce after uterine transplantation or IVF using a gestational surrogate. As uterine transplantation is still an experimental procedure, data on their clinical outcome using assisted reproduction techniques are imperative to allow evidence-based counselling. For this purpose, a systematic non-restricted electronic literature search was conducted. The 14 studies included in this review were published between 1988 and 2011. From a cohort of 140 patients with MRKH syndrome, mostly from the the USA and Israel, only four studies contained data on more than 10 patients; the others were case reports or small series. In the studies reviewed, 125 patients underwent 369 cycles of IVF with gestational surrogacy, and delivered 71 newborns. The reporting of outcome of patients with MRKH syndrome undergoing assisted reproduction techniques in the available literature is less than optimal and is characterized by bias of publication, inconsistent reports, including few patients, treated over a long time span, and lacking systematic reports from large IVF centres. None of the national registries contain specific outcome data on patients with MRKH syndrome. The paucity of data limits the possibility to draw firm conclusions but substantiates the need for a systematic multicentre reporting system.
AB - Women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome may reproduce after uterine transplantation or IVF using a gestational surrogate. As uterine transplantation is still an experimental procedure, data on their clinical outcome using assisted reproduction techniques are imperative to allow evidence-based counselling. For this purpose, a systematic non-restricted electronic literature search was conducted. The 14 studies included in this review were published between 1988 and 2011. From a cohort of 140 patients with MRKH syndrome, mostly from the the USA and Israel, only four studies contained data on more than 10 patients; the others were case reports or small series. In the studies reviewed, 125 patients underwent 369 cycles of IVF with gestational surrogacy, and delivered 71 newborns. The reporting of outcome of patients with MRKH syndrome undergoing assisted reproduction techniques in the available literature is less than optimal and is characterized by bias of publication, inconsistent reports, including few patients, treated over a long time span, and lacking systematic reports from large IVF centres. None of the national registries contain specific outcome data on patients with MRKH syndrome. The paucity of data limits the possibility to draw firm conclusions but substantiates the need for a systematic multicentre reporting system.
KW - MRKH
KW - Mayer-Rokitansky-Kuster-Hauser
KW - Müllerian agenesis/aplasia
KW - gestational surrogacy
UR - http://www.scopus.com/inward/record.url?scp=84954401675&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2015.09.006
DO - 10.1016/j.rbmo.2015.09.006
M3 - Review article
AN - SCOPUS:84954401675
SN - 1472-6483
VL - 32
SP - 54
EP - 61
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 1
ER -