The reproductive potential of patients with Mayer-Rokitansky-Küster-Hauser syndrome using gestational surrogacy: A systematic review

Shevach Friedler, Leonti Grin, Gad Liberti, Buzhena Saar-Ryss, Yaakov Rabinson, Semion Meltzer

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome may reproduce after uterine transplantation or IVF using a gestational surrogate. As uterine transplantation is still an experimental procedure, data on their clinical outcome using assisted reproduction techniques are imperative to allow evidence-based counselling. For this purpose, a systematic non-restricted electronic literature search was conducted. The 14 studies included in this review were published between 1988 and 2011. From a cohort of 140 patients with MRKH syndrome, mostly from the the USA and Israel, only four studies contained data on more than 10 patients; the others were case reports or small series. In the studies reviewed, 125 patients underwent 369 cycles of IVF with gestational surrogacy, and delivered 71 newborns. The reporting of outcome of patients with MRKH syndrome undergoing assisted reproduction techniques in the available literature is less than optimal and is characterized by bias of publication, inconsistent reports, including few patients, treated over a long time span, and lacking systematic reports from large IVF centres. None of the national registries contain specific outcome data on patients with MRKH syndrome. The paucity of data limits the possibility to draw firm conclusions but substantiates the need for a systematic multicentre reporting system.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalReproductive BioMedicine Online
Volume32
Issue number1
DOIs
StatePublished - 1 Jan 2016

Keywords

  • MRKH
  • Mayer-Rokitansky-Kuster-Hauser
  • Müllerian agenesis/aplasia
  • gestational surrogacy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

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