The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access

Jonne Terstappen, Sarah F. Hak, Anant Bhan, Debby Bogaert, Louis J. Bont, Ursula J. Buchholz, Andrew D. Clark, Cheryl Cohen, Ron Dagan, Daniel R. Feikin, Barney S. Graham, Anuradha Gupta, Pradeep Haldar, Rose Jalang'o, Ruth A. Karron, Leyla Kragten, You Li, Yvette N. Löwensteyn, Patrick K. Munywoki, Rosemary NjoguAb Osterhaus, Andrew J. Pollard, Luiza Reali Nazario, Charles Sande, Ashish R. Satav, Padmini Srikantiah, Renato T. Stein, Naveen Thacker, Rachael Thomas, Marta Tufet Bayona, Natalie I. Mazur

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Respiratory syncytial virus (RSV) is the second most common pathogen causing infant mortality. Additionally, RSV is a major cause of morbidity and mortality in older adults (age ≥60 years) similar to influenza. A protein-based maternal vaccine and monoclonal antibody (mAb) are now market-approved to protect infants, while an mRNA and two protein-based vaccines are approved for older adults. First-year experience protecting infants with nirsevimab in high-income countries shows a major public health benefit. It is expected that the RSV vaccine landscape will continue to develop in the coming years to protect all people globally. The vaccine and mAb landscape remain active with 30 candidates in clinical development using four approaches: protein-based, live-attenuated and chimeric vector, mRNA, and mAbs. Candidates in late-phase trials aim to protect young infants using mAbs, older infants and toddlers with live-attenuated vaccines, and children and adults using protein-based and mRNA vaccines. This Review provides an overview of RSV vaccines highlighting different target populations, antigens, and trial results. As RSV vaccines have not yet reached low-income and middle-income countries, we outline urgent next steps to minimise the vaccine delay.

Original languageEnglish
JournalThe Lancet Infectious Diseases
DOIs
StateAccepted/In press - 1 Jan 2024

ASJC Scopus subject areas

  • Infectious Diseases

Fingerprint

Dive into the research topics of 'The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access'. Together they form a unique fingerprint.

Cite this