The road to non-enzymatic molecular networks

Zehavit Dadon, Nathaniel Wagner, Gonen Ashkenasy

Research output: Contribution to journalShort surveypeer-review

122 Scopus citations


This Minireview gives an overview of recent progress in the design and analysis of chemical systems that utilize template-directed autocatalytic and cross-catalytic processes as a means of wiring dynamically interacting molecules. Synthetic networks comprising two to nine replicating species are discussed. It is shown that for larger systems, more catalytic pathways must be manipulated to control the entire network topology and specific functionality of the individual species or subnetworks. Cellular biochemistry is an example of a natural functional molecular network; synthetic self-organized networks can provide additional models of complex systems.

Original languageEnglish
Pages (from-to)6128-6136
Number of pages9
JournalAngewandte Chemie - International Edition
Issue number33
StatePublished - 4 Aug 2008


  • Minimal self-replication
  • Self-organized networks
  • Systems chemistry
  • Template-assisted catalysis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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