The role of antibody and host cells in the resistance of mice against infection by Coxsackie B 3 virus

B. Rager Zisman, A. C. Allison

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Peritoneal exudate cells transferred from adult to suckling BALB/c mice before infection of the recipients with Coxsackie B 3 virus protected them against the lethal effects of the virus. Undiluted antibody alone also prevented lethal virus infections in suckling mice but diluted antibody conferred protection only when transferred together with syngeneic adult peritoneal exudate cells. Impairment of macrophage function by intravenous injection of silica increased the susceptibility to virus infection of adult mice. Peritoneal exudate cells inactivated the virus in vitro, and this property may be related to their protective effect in vivo. It is suggested that antibody and host cells collaborate to provide effective resistance against the spread of Coxsackie virus.

Original languageEnglish
Pages (from-to)329-338
Number of pages10
JournalJournal of General Virology
Volume19
Issue number3
DOIs
StatePublished - 1 Jan 1973
Externally publishedYes

ASJC Scopus subject areas

  • Virology

Fingerprint

Dive into the research topics of 'The role of antibody and host cells in the resistance of mice against infection by Coxsackie B 3 virus'. Together they form a unique fingerprint.

Cite this