Abstract
AT-rich interaction domain 1A gene (ARID1A) encodes for a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, a chromatin remodeling complex, and it has been implicated in the pathogenesis of various cancer types. In this review, we discuss how ARID1A is linked to endometrial cancer and what molecular pathways are affected by mutation or inhibition of ARID1A. We also discuss the potential use of ARID1A not only as a prognostic biomarker, but also as a target for therapeutic interventions.
Original language | English |
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Pages (from-to) | 659-667 |
Number of pages | 9 |
Journal | In Vivo |
Volume | 33 |
Issue number | 3 |
DOIs | |
State | Published - 1 May 2019 |
Keywords
- ARID1A
- Endometrial cancer
- Molecular pathways
- Review
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Pharmacology
- Cancer Research