The role of ARID1A in endometrial cancer and the molecular pathways associated with pathogenesis and cancer progression

Chrisavgi Toumpeki, Anastasios Liberis, Ioannis Tsirkas, Theodora Tsirka, Sofia Kalagasidou, Lola Inagamova, Xanthoula Anthoulaki, Georgios Tsatsaris, Emmanuel N. Kontomanolis

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

AT-rich interaction domain 1A gene (ARID1A) encodes for a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, a chromatin remodeling complex, and it has been implicated in the pathogenesis of various cancer types. In this review, we discuss how ARID1A is linked to endometrial cancer and what molecular pathways are affected by mutation or inhibition of ARID1A. We also discuss the potential use of ARID1A not only as a prognostic biomarker, but also as a target for therapeutic interventions.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalIn Vivo
Volume33
Issue number3
DOIs
StatePublished - 1 May 2019

Keywords

  • ARID1A
  • Endometrial cancer
  • Molecular pathways
  • Review

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology
  • Cancer Research

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