The role of Crk adaptor proteins in T-cell adhesion and migration

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations

Abstract

Crk adaptor proteins are key players in signal transduction from a variety of cell surface receptors. They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules, such as Cbl, ZAP-70, CasL, and STAT5. In addition, they constitutively associate, via their SH3 domain, with effector molecules, such as C3G, that mediate cell adhesion and regulate lymphocyte extravasation and recruitment to sites of inflammation. Recent studies demonstrated that the conformation and function of CrkII is subjected to a regulation by immunophilins, which also affect CrkII-dependent T-cell adhesion to fibronectin and migration toward chemokines. This article addresses mechanisms that regulate CrkII conformation and function, in general, and emphasizes the role of Crk proteins in receptor-coupled signaling pathways that control T-lymphocyte adhesion and migration to inflammatory sites.

Original languageEnglish
Article number509
JournalFrontiers in Immunology
Volume6
Issue numberOCT
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Cell adhesion
  • Cell migration
  • Crk adaptor proteins
  • Cyclophilin A
  • Cyclosporin A
  • Immunophilins
  • Signal transduction
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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