The role of DNA damage and repair in aging through the prism of Koch-like criteria

Alexey A. Moskalev, Mikhail V. Shaposhnikov, Ekaterina N. Plyusnina, Alex Zhavoronkov, Arie Budovsky, Hagai Yanai, Vadim E. Fraifeld

Research output: Contribution to journalReview articlepeer-review

231 Scopus citations


Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great volume of knowledge in the field has been accumulated. Here we attempted to organize the evidence "for" and "against" the hypothesized causal role of DNA damage and mutation accumulation in aging in light of four Koch-like criteria. They are based on the assumption that some quantitative relationship between the levels of DNA damage/mutations and aging rate should exist, so that (i) the longer-lived individuals or species would have a lower rate of damage than the shorter-lived, and (ii) the interventions that modulate the level of DNA damage and repair capacity should also modulate the rate of aging and longevity and vice versa. The analysis of how the existing data meets the proposed criteria showed that many gaps should still be filled in order to reach a clear-cut conclusion. As a perspective, it seems that the main emphasis in future studies should be put on the role of DNA damage in stem cell aging.

Original languageEnglish
Pages (from-to)661-684
Number of pages24
JournalAgeing Research Reviews
Issue number2
StatePublished - 1 Mar 2013
Externally publishedYes


  • Aging
  • DNA damage
  • DNA mutations
  • DNA repair
  • Longevity

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology


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