The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen

Giuseppe Morgante, Raoul Orvieto, Alessandra Di Sabatino, Maria C. Musacchio, Vincenzo De Leo

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%).

Original languageEnglish
Pages (from-to)2642-2644
Number of pages3
JournalFertility and Sterility
Volume95
Issue number8
DOIs
StatePublished - 30 Jun 2011

Keywords

  • PCOS
  • cancellation rate
  • gonadotropin
  • inositol
  • insulin resistance
  • ovulation induction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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