The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen

Giuseppe Morgante; Raoul Orvieto; Alessandra Di Sabatino; Maria C. Musacchio; Vincenzo De Leo

doi:10.1016/j.fertnstert.2011.01.035

The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen

Giuseppe Morgante
, Raoul Orvieto
, Alessandra Di Sabatino
, Maria C. Musacchio
, Vincenzo De Leo

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%).

Original language	English
Pages (from-to)	2642-2644
Number of pages	3
Journal	Fertility and Sterility
Volume	95
Issue number	8
DOIs	https://doi.org/10.1016/j.fertnstert.2011.01.035
State	Published - 30 Jun 2011

Keywords

cancellation rate
gonadotropin
inositol
insulin resistance
ovulation induction
PCOS

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.fertnstert.2011.01.035

Cite this

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title = "The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen",

abstract = "In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40\%) and the consequent improvement in clinical pregnancy rate (PR) (33.3\% vs. 13.3\%).",

keywords = "cancellation rate, gonadotropin, inositol, insulin resistance, ovulation induction, PCOS",

author = "Giuseppe Morgante and Raoul Orvieto and \{Di Sabatino\}, Alessandra and Musacchio, \{Maria C.\} and \{De Leo\}, Vincenzo",

year = "2011",

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doi = "10.1016/j.fertnstert.2011.01.035",

language = "English",

volume = "95",

pages = "2642--2644",

journal = "Fertility and Sterility",

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The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. / Morgante, Giuseppe; Orvieto, Raoul; Di Sabatino, Alessandra et al.
In: Fertility and Sterility, Vol. 95, No. 8, 30.06.2011, p. 2642-2644.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen

AU - Morgante, Giuseppe

AU - Orvieto, Raoul

AU - Di Sabatino, Alessandra

AU - Musacchio, Maria C.

AU - De Leo, Vincenzo

PY - 2011/6/30

Y1 - 2011/6/30

N2 - In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%).

AB - In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%).

KW - cancellation rate

KW - gonadotropin

KW - inositol

KW - insulin resistance

KW - ovulation induction

KW - PCOS

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DO - 10.1016/j.fertnstert.2011.01.035

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AN - SCOPUS:79956359964

SN - 0015-0282

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JO - Fertility and Sterility

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IS - 8

ER -

The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen

Abstract

Keywords

ASJC Scopus subject areas

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