The role of intravenous immunoglobulin in the prevention of severe ovarian hyperstimulation syndrome

Raoul Orvieto, Anatl Achiron, Raanan Margalit, Zion Ben-Rafael

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Purpose: The role of intravenous immunoglobulin (IVIG) in the prevention of severe ovarian hyperstimulation syndrome (OHSS) was evaluated. Methods: Ovarian hyperstimulation was induced in eight rabbits using human menopausal gonadotropin/human chorionic gonadotropin (hMG/hCG) after pretreatment with IVIG (IVIG group) or bovine serum albumin (BSA group). Main outcome measures included (1) signs of OHSS, such as the degree of ascites formation and the increase in body weight; and (2) the degree of ovarian stimulation as reflected by serum sex-steroid hormone levels. Results: A significantly lower ascites response and a tendency toward a decreased change in body weight were observed in the IVIG group compared to the BSA group. Serum estradiol, progesterone, total protein, and ovarian weights were not statistically different between the two groups. Conclusions: IVIG prevented severe OHSS in a rabbit model, whereas BSA did not. Further studies are justified in an attempt to clarify the role of the immune system and IVIG in the pathophysiology and prevention of severe OHSS.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Volume15
Issue number1
DOIs
StatePublished - 12 Mar 1998
Externally publishedYes

Keywords

  • Albumin
  • Immune system
  • Intravenous immunoglobulin
  • Ovarian hyperstimulation syndrome
  • Prevention

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