The Role of Mitochondria in Oocyte and Early Embryo Health

Kyunga Kim; Shlomit Kenigsberg; Andrea Jurisicova; Yaakov Bentov

doi:10.21926/obm.genet.1901070

The Role of Mitochondria in Oocyte and Early Embryo Health

Kyunga Kim, Shlomit Kenigsberg, Andrea Jurisicova, Yaakov Bentov

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The mitochondria of the oocyte are a prominent source of energy metabolism as well as mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries provided new insight into the physiology of the mitochondria and its unique genetics. The concept of heteroplasmy defined as the presence of more than one type of mitochondrial genome, is gaining increasing recognition as an important contributor to several complex morbidities, age-related reproductive dysfunction and aging. Understanding the changes caused by pathogenic mutations as well as identifying defects occurring during reproductive aging will enhance our knowledge of the role of mitochondria as organelles in germ cell biology. In this review, we summarize the current state of knowledge about the role of mitochondria in embryo and fetal development.

Original language	English
Article number	70
Journal	OBM Genetics
Volume	3
Issue number	1
DOIs	https://doi.org/10.21926/obm.genet.1901070
State	Published - 1 Oct 2019
Externally published	Yes

Keywords

Mitochondria
heteroplasmy
mitochondrial dysfunction
mitochondrial transfer
mtDNA
oxidative phosphorylation

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cell Biology

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10.21926/obm.genet.1901070

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title = "The Role of Mitochondria in Oocyte and Early Embryo Health",

abstract = "The mitochondria of the oocyte are a prominent source of energy metabolism as well as mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries provided new insight into the physiology of the mitochondria and its unique genetics. The concept of heteroplasmy defined as the presence of more than one type of mitochondrial genome, is gaining increasing recognition as an important contributor to several complex morbidities, age-related reproductive dysfunction and aging. Understanding the changes caused by pathogenic mutations as well as identifying defects occurring during reproductive aging will enhance our knowledge of the role of mitochondria as organelles in germ cell biology. In this review, we summarize the current state of knowledge about the role of mitochondria in embryo and fetal development.",

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AU - Kim, Kyunga

AU - Kenigsberg, Shlomit

AU - Jurisicova, Andrea

AU - Bentov, Yaakov

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The mitochondria of the oocyte are a prominent source of energy metabolism as well as mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries provided new insight into the physiology of the mitochondria and its unique genetics. The concept of heteroplasmy defined as the presence of more than one type of mitochondrial genome, is gaining increasing recognition as an important contributor to several complex morbidities, age-related reproductive dysfunction and aging. Understanding the changes caused by pathogenic mutations as well as identifying defects occurring during reproductive aging will enhance our knowledge of the role of mitochondria as organelles in germ cell biology. In this review, we summarize the current state of knowledge about the role of mitochondria in embryo and fetal development.

AB - The mitochondria of the oocyte are a prominent source of energy metabolism as well as mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries provided new insight into the physiology of the mitochondria and its unique genetics. The concept of heteroplasmy defined as the presence of more than one type of mitochondrial genome, is gaining increasing recognition as an important contributor to several complex morbidities, age-related reproductive dysfunction and aging. Understanding the changes caused by pathogenic mutations as well as identifying defects occurring during reproductive aging will enhance our knowledge of the role of mitochondria as organelles in germ cell biology. In this review, we summarize the current state of knowledge about the role of mitochondria in embryo and fetal development.

KW - Mitochondria

KW - heteroplasmy

KW - mitochondrial dysfunction

KW - mitochondrial transfer

KW - mtDNA

KW - oxidative phosphorylation

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The Role of Mitochondria in Oocyte and Early Embryo Health

Abstract

Keywords

ASJC Scopus subject areas

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