The Role of m6A/m-RNA Methylation in Stress Response Regulation

Mareen Engel; Carola Eggert; Paul M. Kaplick; Matthias Eder; Simone Röh; Lisa Tietze; Christian Namendorf; Janine Arloth; Peter Weber; Monika Rex-Haffner; Shay Geula; Mira Jakovcevski; Jacob H. Hanna; Dena Leshkowitz; Manfred Uhr; Carsten T. Wotjak; Mathias V. Schmidt; Jan M. Deussing; Elisabeth B. Binder; Alon Chen

doi:10.1016/j.neuron.2018.07.009

The Role of m⁶A/m-RNA Methylation in Stress Response Regulation

Mareen Engel
, Carola Eggert
, Paul M. Kaplick
, Matthias Eder
, Simone Röh
, Lisa Tietze
, Christian Namendorf
, Janine Arloth
, Peter Weber
, Monika Rex-Haffner
, Shay Geula
, Mira Jakovcevski
, Jacob H. Hanna
, Dena Leshkowitz
, Manfred Uhr
, Carsten T. Wotjak
, Mathias V. Schmidt
, Jan M. Deussing
, Elisabeth B. Binder
, Alon Chen

Research output: Contribution to journal › Article › peer-review

343 Scopus citations

Abstract

Engel et al. demonstrate a region- and time-dependent role of brain m⁶A/m methylation in stress-response regulation. Manipulating m⁶A/m alters fear memory, transcriptome response, and synaptic plasticity. Altered m⁶A/m dynamics in depressed patients suggest importance of m⁶A/m modifications for stress-related psychiatric disorders.

Original language	English
Pages (from-to)	389-403.e9
Journal	Neuron
Volume	99
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2018.07.009
State	Published - 25 Jul 2018
Externally published	Yes

Keywords

Fto
Mettl3
RNA modification
mA
mAm
major depressive disorder
post-transcriptional regulation
stress

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.neuron.2018.07.009

Cite this

Engel, M., Eggert, C., Kaplick, P. M., Eder, M., Röh, S., Tietze, L., Namendorf, C., Arloth, J., Weber, P., Rex-Haffner, M., Geula, S., Jakovcevski, M., Hanna, J. H., Leshkowitz, D., Uhr, M., Wotjak, C. T., Schmidt, M. V., Deussing, J. M., Binder, E. B., & Chen, A. (2018). The Role of m⁶A/m-RNA Methylation in Stress Response Regulation. Neuron, 99(2), 389-403.e9. https://doi.org/10.1016/j.neuron.2018.07.009

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abstract = "Engel et al. demonstrate a region- and time-dependent role of brain m6A/m methylation in stress-response regulation. Manipulating m6A/m alters fear memory, transcriptome response, and synaptic plasticity. Altered m6A/m dynamics in depressed patients suggest importance of m6A/m modifications for stress-related psychiatric disorders.",

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Engel, M, Eggert, C, Kaplick, PM, Eder, M, Röh, S, Tietze, L, Namendorf, C, Arloth, J, Weber, P, Rex-Haffner, M, Geula, S, Jakovcevski, M, Hanna, JH, Leshkowitz, D, Uhr, M, Wotjak, CT, Schmidt, MV, Deussing, JM, Binder, EB & Chen, A 2018, 'The Role of m⁶A/m-RNA Methylation in Stress Response Regulation', Neuron, vol. 99, no. 2, pp. 389-403.e9. https://doi.org/10.1016/j.neuron.2018.07.009

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