The role of protein kinase C in G1 and G2/M phases of the cell cycle (Review)

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


The protein serine/threonine kinases - members of protein kinase C (PKC) family - are important components of the major signaling pathways regulating cell proliferation and differentiation. Recent studies implicate PKC in cell cycle control at two sites - during G1 to S progression and at G2 to M transition. Activation of PKC during G1 progression modulates the activity of the specific cyclin-dependent kinases (CDKs), which phosphorylate the retinoblastoma susceptibility gene product (RB). Phosphorylation of RB is a pivotal event in cell cycle progression leading to G1/S transition. PKC mediated enhancement or inhibition of CDK's activity and the RB phosphorylation state appear to be dependent on the precise timing of PKC activation during G1 and on the particular cell type. At G2/M transition, recent evidence suggests that PKC is involved in the regulation of CDC2 activity, although it is mostly implicated as a regulator of lamin B phosphorylation and the nuclear lamina disassembly.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalInternational Journal of Oncology
Issue number1
StatePublished - 1 Jan 1998


  • CDK activating kinase
  • Cell-cycle
  • Cyclin
  • Cyclin-dependent inase
  • Phorbol esters
  • Protein kinase C
  • Retinoblastoma protein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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