The role of the immune system in severe ovarian hyperstimulation syndrome

R. Orvieto, Z. Ben-Rafael

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The ovarian hyperstimulation syndrome is a serious, and potentially life-threatening, complication of ovulation induction. Hitherto, there has been no reliable test which will predict patients who will subsequently develop ovarian hyperstimulation syndrome. Recently, evidences have accumulated concerning the interaction between the immune and reproductive systems which results from sharing certain lymphohaematopoietic cytokines and their receptors. Furthermore, several cytokines have been implicated in the prediction and pathophysiology of ovarian hyperstimulation syndrome. If this is true, it may be possible to modify the patients' immunological homeostasis by passive immunization with intravenous immunoglobulin (IVIg) and thus to prevent ovarian hyperstimulation syndrome.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalMedical Hypotheses
Issue number3
StatePublished - 1 Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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