The Role of Tomato Lycopene in Cancer Prevention

Joseph Levy; Shlomo Walfisch; Andrea Atzmon; Keren Hirsch; Marina Khanin; Karin Linnewiel; Yael Morag; Hagar Salman; Anna Veprik; Michael Danilenko; Yoav Sharoni

doi:10.1007/978-90-481-9800-9_3

The Role of Tomato Lycopene in Cancer Prevention

Joseph Levy, Shlomo Walfisch, Andrea Atzmon, Keren Hirsch, Marina Khanin, Karin Linnewiel, Yael Morag, Hagar Salman, Anna Veprik, Michael Danilenko, Yoav Sharoni

Basic Sciences Divisions

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.

Original language	English
Title of host publication	Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention
Editors	Marja Mutanen, Anne-Maria Pajari
Publisher	Springer, Dordrecht
Pages	47-66
ISBN (Electronic)	9789048198009
ISBN (Print)	9789048197996, 9789400733800
DOIs	https://doi.org/10.1007/978-90-481-9800-9_3
State	Published - Oct 2011

Publication series

Name	Diet and Cancer
Publisher	Springer
Volume	2

Keywords

Tomato lycopene
Phase II enzymes
Growth factors
Sex hormones
Chemoprevention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-90-481-9800-9_3

Cite this

Levy, J., Walfisch, S., Atzmon, A., Hirsch, K., Khanin, M., Linnewiel, K., Morag, Y., Salman, H., Veprik, A., Danilenko, M., & Sharoni, Y. (2011). The Role of Tomato Lycopene in Cancer Prevention. In M. Mutanen, & A.-M. Pajari (Eds.), Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention (pp. 47-66). (Diet and Cancer; Vol. 2). Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9800-9_3

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title = "The Role of Tomato Lycopene in Cancer Prevention",

abstract = "The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.",

keywords = "Tomato lycopene, Phase II enzymes, Growth factors, Sex hormones, Chemoprevention",

author = "Joseph Levy and Shlomo Walfisch and Andrea Atzmon and Keren Hirsch and Marina Khanin and Karin Linnewiel and Yael Morag and Hagar Salman and Anna Veprik and Michael Danilenko and Yoav Sharoni",

year = "2011",

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doi = "10.1007/978-90-481-9800-9_3",

language = "English",

isbn = "9789048197996",

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Levy, J, Walfisch, S, Atzmon, A, Hirsch, K, Khanin, M, Linnewiel, K, Morag, Y, Salman, H, Veprik, A, Danilenko, M & Sharoni, Y 2011, The Role of Tomato Lycopene in Cancer Prevention. in M Mutanen & A-M Pajari (eds), Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention. Diet and Cancer, vol. 2, Springer, Dordrecht, pp. 47-66. https://doi.org/10.1007/978-90-481-9800-9_3

TY - CHAP

T1 - The Role of Tomato Lycopene in Cancer Prevention

AU - Levy, Joseph

AU - Walfisch, Shlomo

AU - Atzmon, Andrea

AU - Hirsch, Keren

AU - Khanin, Marina

AU - Linnewiel, Karin

AU - Morag, Yael

AU - Salman, Hagar

AU - Veprik, Anna

AU - Danilenko, Michael

AU - Sharoni, Yoav

PY - 2011/10

Y1 - 2011/10

N2 - The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.

AB - The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.

KW - Tomato lycopene

KW - Phase II enzymes

KW - Growth factors

KW - Sex hormones

KW - Chemoprevention

U2 - 10.1007/978-90-481-9800-9_3

DO - 10.1007/978-90-481-9800-9_3

M3 - Chapter

SN - 9789048197996

SN - 9789400733800

T3 - Diet and Cancer

SP - 47

EP - 66

BT - Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention

A2 - Mutanen, Marja

A2 - Pajari, Anne-Maria

PB - Springer, Dordrecht

ER -

The Role of Tomato Lycopene in Cancer Prevention

Abstract

Publication series

Keywords

UN SDGs

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