בטיחותם ויעילותם של החיסונים כנגד שפעת A/H1N1 2009

Translated title of the contribution: The safety and immunogenicity of the vaccines against pandemic (H1N1) 2009 influenza

איתמר גרוטו, דן אנגלהרד

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The current pandemic (H1N1) 2009 influenza is spreading worldwide with a significant increase in morbidity and mortality noted in Israel, as well as in many other countries of the Northern Hemisphere. In an attempt to minimize severe morbidity and mortality, immunization projects have been initiated. This review describes the scientific data regarding safety and immunogenicity of the pandemic (H1N1) influenza vaccines which were approved for use in Israel. The approval was based on: (1) broad experience with seasonal flu vaccines; (2) data from the research and development processes of pandemic vaccines; (3) experience with adjuvants used in other vaccines and (4) post-marketing data. The immunogenicity of the approved vaccines is excellent: at least 92% develop protective antibody titers following a single vaccine dose. The vaccines are considered safe and severe side effects are very rare. Mild and transient adverse effects are similar to those following seasonal flu vaccines: local side effects in up to 12-18% and systemic adverse effects in up to 8%. The safety of the adjuvants and thiomersal is described in this review. The vaccines currently used in Israel were approved by the European Medicines Agency (EMEA) after the agency was satisfied with available safety data. Finally, the current pandemic 2009 (H1N1) influenza immunization program in Israel is described.
Translated title of the contributionThe safety and immunogenicity of the vaccines against pandemic (H1N1) 2009 influenza
Original languageHebrew
Pages (from-to)799-803
Number of pages5
Journalהרפואה
Volume148
Issue number12
StatePublished - Dec 2009

IHP Publication

  • ihp
  • H1N1 influenza
  • Influenza vaccines
  • Public health
  • בריאות הציבור
  • חיסון נגד שפעת
  • פנדמיה
  • שפעת החזירים

Fingerprint

Dive into the research topics of 'The safety and immunogenicity of the vaccines against pandemic (H1N1) 2009 influenza'. Together they form a unique fingerprint.

Cite this