The safety of H2-blockers use during pregnancy

Ilan Matok, Rafael Gorodischer, Gideon Koren, Eyal Sheiner, Arnon Wiznitzer, Elia Uziel, Amalia Levy

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Little data exist on the safety of H2-blockers during pregnancy. A computerized database of medications dispensed from 1998 to 2007 to all women registered in the Clalit health maintenance organization, in the Southern District of Israel, was linked with computerized databases containing maternal and infant hospitalization records from the district hospital. The following confounders were controlled for: parity, maternal age, ethnic group, maternal diabetes, smoking, and peripartum fever. Also, therapeutic pregnancy termination data were analyzed. A total of 117 960 infants were born during the study period, 84 823 of them (72%) to women registered at Clalit 1148 of the latter were exposed to H2-blockers during the first trimester of pregnancy. Exposure to H2-blockers was not associated with an increased risk for congenital malformations (adjusted odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.80-1.32); also, no such association was found when therapeutic pregnancy terminations were included in the analysis (adjusted OR = 1.17, 95% CI: 0.93-1.46). Exposure to H2-blockers was not associated with perinatal mortality, premature delivery, low birth weight, or low Apgar scores.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalJournal of Clinical Pharmacology
Volume50
Issue number1
DOIs
StatePublished - 1 Jan 2010

Keywords

  • Data bases
  • Drug safety
  • H-blockers
  • Linkage
  • Pregnancy

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