The syndrome of congenital adrenal hyperplasia in Israel

B. Porter, M. Finzi, E. Leiberman, S. Moses

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Congenital adrenal hyperplasia (CAH) is caused by an enzymatic defect at one of the various stages of steroid hormone synthesis in the adrenal gland. As a result of these defects, cortisol production is impaired, and uninhibited ACTH release occurs; increased amounts of intermediary steroids are produced, many of which have an anabolic effect, resulting in the clinical syndrome. A survey of cases of congenital adrenal hyperplasia in Israel revealed an unusually high incidence of the disease in general, and particularly of the 11-hydroxylase deficiency type, among Jews of North African origin. This disease thus joins a list of a number of genetic inborn errors of metabolism occurring with increased frequency in this population.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
Issue number2
StatePublished - 1 Jan 1977

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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