TY - JOUR
T1 - The Systems Chemistry of Nucleic-acid-Peptide Networks
AU - Kumar Bandela, Anil
AU - Sadihov-Hanoch, Hava
AU - Cohen-Luria, Rivka
AU - Gordon, Christella
AU - Blake, Alexis
AU - Poppitz, George
AU - Lynn, David G.
AU - Ashkenasy, Gonen
N1 - Publisher Copyright:
© 2022 The Authors. Israel Journal of Chemistry published by Wiley-VCH GmbH.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Living cells use chemical building blocks (biopolymers) to form fascinatingly complex architectures, which in turn display multiple functions necessary for the cell life cycle. The mechanisms and order of events by which forerunners of these extant biopolymers formed on the early earth remains under intensive investigation. Prebiotic chemistry research has recently provided ample evidence that both peptide and nucleic-acid (NA) precursors could be formed in a primordial environment through common synthetic routes. However, until recently, studies directed at the design of functional supramolecular structures have focused primarily on assemblies made of either peptides or NAs. The emerging discipline of Systems Chemistry now develops dynamic supramolecular interactions to capture the complex emergent properties of reaction networks. Accordingly, we review here recent work that reveals mutualistic nucleic acid/peptide co-assembly, and approaches toward utility of these architectures as functional materials capable of substrate binding, catalysis, replication, and translation. Many of these new approaches to smart soft biomaterials and functional bio-nanotechnology provide insight and extend our understanding of the possible origins of living systems.
AB - Living cells use chemical building blocks (biopolymers) to form fascinatingly complex architectures, which in turn display multiple functions necessary for the cell life cycle. The mechanisms and order of events by which forerunners of these extant biopolymers formed on the early earth remains under intensive investigation. Prebiotic chemistry research has recently provided ample evidence that both peptide and nucleic-acid (NA) precursors could be formed in a primordial environment through common synthetic routes. However, until recently, studies directed at the design of functional supramolecular structures have focused primarily on assemblies made of either peptides or NAs. The emerging discipline of Systems Chemistry now develops dynamic supramolecular interactions to capture the complex emergent properties of reaction networks. Accordingly, we review here recent work that reveals mutualistic nucleic acid/peptide co-assembly, and approaches toward utility of these architectures as functional materials capable of substrate binding, catalysis, replication, and translation. Many of these new approaches to smart soft biomaterials and functional bio-nanotechnology provide insight and extend our understanding of the possible origins of living systems.
UR - http://www.scopus.com/inward/record.url?scp=85137019530&partnerID=8YFLogxK
U2 - 10.1002/ijch.202200030
DO - 10.1002/ijch.202200030
M3 - Review article
AN - SCOPUS:85137019530
SN - 0021-2148
VL - 62
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 9-10
M1 - e202200030
ER -