The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

Peleg Rider, Irena Kaplanov, Marianna Romzova, Liora Braiman, Alex Braiman, Elena Voronov, Ron N. Apte

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

During hypoxia, cells undergo transcriptional changes to adjust to metabolic stress, to pro- mote cell survival, and to induce pro-angiogenic factors. Hypoxia-induced factors (HIFs) regulate these transcriptional alterations. Failure to restore oxygen levels results in cell death by necrosis. IL-1α is one of the most important mediators of sterile inflammation following hypoxia-mediated necrosis. During hypoxia, IL-1α is up-regulated and released from necrotic cells, promoting the initiation of sterile inflammation. This study examined the role of IL-1α transcription in initiation of hypoxic stress and the correlation between IL-1α transcription and HIFα factors. In an epithelial cell line cultured under hypoxic condi- tions, IL-1α transcription was up-regulated in a process mediated and promoted by HIFα factors. IL-1α transcription was also up-regulated in hypoxia in a fibroblast cell line, how- ever, in these cells, HIFα factors inhibited the elevation of transcription.These data suggest that HIFα factors play a significant role in initiating sterile inflammation by controlling IL-1α transcription during hypoxia in a differential manner, depending on the cell type.

Original languageEnglish
Article numberArticle 290
JournalFrontiers in Immunology
Volume3
Issue numberSEP
DOIs
StatePublished - 1 Dec 2012

Keywords

  • Alarmin
  • Cytokines and inflammation
  • DAMPs
  • HIF-1α
  • HIF-2
  • IL-1
  • Sterile inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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