The type a and type b polysaccharide capsules predominate in an international collection of invasive Kingella kingae isolates

Eric A. Porsch, Kimberly F. Starr, Pablo Yagupsky, Joseph W. St. Geme

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Kingella kingae is an encapsulated Gram-negative bacterium and an important etiology of osteoarticular infections in young children. A recent study examining a diverse collection of carrier and invasive K. kingae isolates from Israel revealed four distinct polysaccharide capsule types. In this study, to obtain a global view of K. kingae capsule type diversity, we examined an international collection of isolates using a multiplex PCR approach. The collection contained all four previously identified capsule types and no new capsule types. Over 95% of invasive isolates in the collection were type a or type b, similar to the findings in Israel. These results suggest that the type a and type b polysaccharide capsules may have enhanced pathogenic properties or may mark clonal groups of strains with specific virulence genes. In addition, they raise the possibility that a vaccine containing the type a and type b capsules might be an effective approach to preventing K. kingae disease.

Original languageEnglish
Article numbere00060-17
JournalmSphere
Volume2
Issue number2
DOIs
StatePublished - 1 Mar 2017
Externally publishedYes

Keywords

  • Capsule typing
  • Clinical isolates
  • Kingella kingae
  • PCR
  • Polysaccharide capsule

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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