TY - JOUR
T1 - The use of interferons in respiratory diseases
AU - Benhamou, Ori Michael J.
AU - Jacobs, Miriam
AU - Drew, Jonathan
AU - Geva, Shahar
AU - Waldman, Maor
AU - Kalchiem-Dekel, Or
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Interferons (IFNs) are a subclass of lymphocyte-released cytokines that interfere with intracellular viral replication. These drugs are classified into three groups: IFN type 1 (IFN-α, IFN-ß, and IFN-ω), IFN type 2 (IFN-γ), and IFN type 3 (IFN-λ). Despite numerous trials, IFN therapy has yet to conclusively demonstrate superiority in the treatment of various pulmonary diseases. In addition to the FDA-approved and ongoing investigational uses for IFN therapy, there is a debate regarding the appropriate dosage of these agents. A retrospective literature review is moving experts towards low-dose therapies in nearly every application of IFN therapy. It is speculated that known and unknown toxicity may limit the beneficial effects of IFN therapy.
AB - Interferons (IFNs) are a subclass of lymphocyte-released cytokines that interfere with intracellular viral replication. These drugs are classified into three groups: IFN type 1 (IFN-α, IFN-ß, and IFN-ω), IFN type 2 (IFN-γ), and IFN type 3 (IFN-λ). Despite numerous trials, IFN therapy has yet to conclusively demonstrate superiority in the treatment of various pulmonary diseases. In addition to the FDA-approved and ongoing investigational uses for IFN therapy, there is a debate regarding the appropriate dosage of these agents. A retrospective literature review is moving experts towards low-dose therapies in nearly every application of IFN therapy. It is speculated that known and unknown toxicity may limit the beneficial effects of IFN therapy.
KW - Asthma
KW - Idiopathic pulmonary fibrosis
KW - Influenza
KW - Interferon
UR - http://www.scopus.com/inward/record.url?scp=84904115517&partnerID=8YFLogxK
U2 - 10.2174/1573398x10666140520004706
DO - 10.2174/1573398x10666140520004706
M3 - Review article
AN - SCOPUS:84904115517
SN - 1573-398X
VL - 9
SP - 318
EP - 322
JO - Current Respiratory Medicine Reviews
JF - Current Respiratory Medicine Reviews
IS - 5
ER -
